# Formula: percent polymer complexed

Parent: — · class: other · names as written: percent polymer complexed (supernatant mass balance)

2 instances in 2 papers (of 207 kept papers). Each section heading ends with the paper's category / subcategory. Generated by tools/build_evidence.py from registry/formulas.csv; do not edit.

## 2024 Bapat · E2 · percent polymer complexed (supernatant mass balance) · Dissolution / A. Release mechanism and LoC

[2024-bapat-hpmcas-drug-polymer-complexation-release-performance](../../../cards/2024-bapat-hpmcas-drug-polymer-complexation-release-performance/paper.html) · Dissolution / A. Release mechanism and LoC

- expression: % polymer complexed = (1 − polymer in the supernatant/total polymer in the solution) × 100
- symbols and units: polymer in the supernatant after ultracentrifugation; total polymer added
- assumptions stated: HPMCAS alone is fully soluble at pH 6.0 and polymer in the pellet is complexed (C8)
- used for: R11-R13, R16
- status: printed, checked against page image · recomputed: inputs not printed
- locator: p.1469

## 2025 Bapat · E2 · percent polymer complexed (supernatant mass balance) · Dissolution / A. Release mechanism and LoC

[2025-bapat-hpmcas-grade-weak-base-asd-release-complexation](../../../cards/2025-bapat-hpmcas-grade-weak-base-asd-release-complexation/paper.html) · Dissolution / A. Release mechanism and LoC

- expression: % polymer complexed = (1 − polymer in the supernatant/total polymer in the solution) × 100
- symbols and units: polymer in the supernatant measured colorimetrically (P4); total polymer 0.5 mg/mL
- assumptions stated: equivalent polymer alone is fully soluble (C9)
- used for: R9, R10, R11, R12
- status: printed, checked against page image · recomputed: inputs not printed (supernatant polymer concentrations not printed)
- locator: p.400