# Formula: octanol-water partition coefficient

Parent: partition coefficient · class: mixing and phase equilibria · names as written: octanol-water partition coefficient

2 instances in 2 papers (of 207 kept papers). Each section heading ends with the paper's category / subcategory. Generated by tools/build_evidence.py from registry/formulas.csv; do not edit.

## 2020 Saboo · E5 · octanol-water partition coefficient · Dissolution / A. Release mechanism and LoC

[2020-saboo-asd-drug-loading-polymer-hydrophobicity-release](../../../cards/2020-saboo-asd-drug-loading-polymer-hydrophobicity-release/paper.html) · Dissolution / A. Release mechanism and LoC

- expression: log P = log([drug concentration]_octanol / [drug concentration]_aqueous buffer)
- symbols and units: drug concentrations in each phase by LC-MS
- assumptions stated: compounds predominantly un-ionized; pH 6.5 buffer saturated with octanol
- used for: log P of M2, M3
- status: printed, checked against page image · recomputed: inputs not printed (phase concentrations)
- locator: SI p.8

## 2020 Saboo · E4 · octanol-water partition coefficient · Dissolution / A. Release mechanism and LoC

[2020-saboo-congruent-release-hbond-crystallization-tg-pvpva-asd](../../../cards/2020-saboo-congruent-release-hbond-crystallization-tg-pvpva-asd/paper.html) · Dissolution / A. Release mechanism and LoC

- expression: logP = log([drug concentration]octanol/[drug concentration]aqueous buffer)
- symbols and units: concentrations by LC-MS in each phase
- assumptions stated: drug predominantly unionized at the aqueous pH
- used for: M1, M2 (logP)
- status: printed, checked against page image · recomputed: inputs not printed (phase concentrations)
- locator: SI p.3