# Evidence: water sorption isotherm

Parent: water sorption · class: solid-state property · names merged here: moisture sorption isotherm; water sorption isotherm

3 papers measured or used it, 0 only mentioned it (of 207 kept papers). Papers in year order; each section heading ends with the paper's category / subcategory. Generated by tools/build_evidence.py from registry/concepts.csv and the cards; do not edit.

## 2010 Rumondor — Analysis of the Moisture Sorption Behavior of Amorphous Drug–Polymer Blends · Solid state stability / Physical stability

[2010-rumondor-moisture-sorption-amorphous-drug-polymer-blends](../../../cards/2010-rumondor-moisture-sorption-amorphous-drug-polymer-blends/paper.html) · Solid state stability / Physical stability · measured · as: moisture sorption isotherm

| id | kind | content | locator |
|---|---|---|---|
| R1 | record, measured | equilibrium moisture uptake of the single components (g/100 g dry basis) — PVP, HPMC, HPMCAS, amorphous indomethacin, amorphous felodipine; P2, 25 °C — sub-table below; text ranking: PVP sorbs more than the other four at the same RH; HPMC more than HPMCAS; indomethacin more than felodipine | Fig. 1, p.1057; text p.1056-1057 |
| R2 | record, measured | moisture uptake of felodipine–PVP blends (g/100 g dry basis) — 0, 10, 25, 50, 75, 90, 100% PVP (dry weight); P1, P2, 25 °C — sub-table below; at every RH uptake rises with PVP content | Fig. 2, p.1057 |
| R3 | record, measured | moisture uptake of felodipine–HPMC blends (g/100 g dry basis) — 0, 10, 25, 50, 75, 90, 100% HPMC (dry weight, Fig. 3 legend); P1, P2, 25 °C — sub-table below; at every RH uptake rises with HPMC content | Fig. 3, p.1057 |
| R4 | record, measured | moisture uptake of felodipine–HPMCAS blends (g/100 g dry basis) — 0, 15, 25, 50, 70, 85, 100% HPMCAS (dry weight, Fig. 4 legend); P1, P2, 25 °C — sub-table below; at every RH uptake rises with HPMCAS content | Fig. 4, p.1058 |
| R5 | record, measured | moisture uptake of indomethacin–PVP blends (g/100 g dry basis) — 0, 10, 25, 50, 75, 90, 100% PVP (dry weight); P1, P2, 25 °C — sub-table below; at every RH uptake rises with PVP content | Fig. 5, p.1058 |
| P2 | method | gravimetric water vapour sorption isotherm | p.1056 |

## 2010 Rumondor — Effect of Polymer Hygroscopicity on the Phase Behavior of Amorphous Solid Dispersions in the Presence of Moisture · Solid state stability / Physical stability

[2010-rumondor-polymer-hygroscopicity-moisture-phase-separation-asd](../../../cards/2010-rumondor-polymer-hygroscopicity-moisture-phase-separation-asd/paper.html) · Solid state stability / Physical stability · used · as: water sorption isotherm

| id | kind | content | locator |
|---|---|---|---|
| R19 | record, cited | water sorption isotherms (g water/100 g dry solid) — PVP, PVPVA, HPMCAS at 25 °C (refs 9, 34) — sub-table below; all values ≈, read from Fig. 11 | Fig. 11, p.489 |

## 2013 Ilevbare — Liquid-Liquid Phase Separation in Highly Supersaturated Aqueous Solutions of Poorly-Water Soluble Drugs – Implications for Solubility Enhancing Formulations · Dissolution / C. Amorphous solubility and LLPS

[2013-ilevbare-llps-supersaturated-poorly-water-soluble-drugs](../../../cards/2013-ilevbare-llps-supersaturated-poorly-water-soluble-drugs/paper.html) · Dissolution / C. Amorphous solubility and LLPS · measured · as: water sorption isotherm

| id | kind | content | locator |
|---|---|---|---|
| R7 | record, measured and derived (E14) | water sorption isotherm of amorphous ritonavir — 37 °C (P15) — % weight gain ≈0.0 at 0, ≈0.07 at 5, ≈0.17 at 10, ≈0.28 at 15, ≈0.40 at 20, ≈0.53 at 25, ≈0.69 at 30, ≈0.86 at 35, ≈1.05 at 40, ≈1.28 at 45, ≈1.55 at 50, ≈1.86 at 55, ≈2.2 at 60, ≈2.53 at 65, ≈2.87 at 70, ≈3.2 at 75, ≈3.63 at 80, ≈4.1 at 85, ≈4.58 at 90 and ≈4.98 at 95% RH (read from Fig. 6); legend: linear fit of the high-water region, slope 0.075, intercept -2.290, R² 0.9912; caption: estimated weight gain at 100% RH 5.21% | Fig. 6, p.30 |
| E14 | equation | linear extrapolation of the water sorption isotherm to 100% RH: % weight gain = 0.075 × %RH − 2.290 (R² 0.9912) | Fig. 6, p.30 |