# Evidence: tie line

Parent: — · class: phase behaviour · names merged here: tie line

2 papers measured or used it, 0 only mentioned it (of 207 kept papers). Papers in year order; each section heading ends with the paper's category / subcategory. Generated by tools/build_evidence.py from registry/concepts.csv and the cards; do not edit.

## 2023 Deac — Dissolution Mechanisms of Amorphous Solid Dispersions: Role of Drug Load and Molecular Interactions · Dissolution / A. Release mechanism and LoC

[2023-deac-asd-drug-load-molecular-interactions-loc](../../../cards/2023-deac-asd-drug-load-molecular-interactions-loc/paper.html) · Dissolution / A. Release mechanism and LoC · used · as: tie line

| id | kind | content | locator |
|---|---|---|---|
| C48 | claim, generalisation, authors: asserted | Associative separation gives positively sloped tie lines with the plait point on the left (low drug) side of the diagram; segregative separation gives negatively sloped tie lines with the plait point on the right [rests on: argument only (Fig. 9)] | p.733 |
| C53 | claim, mechanism, authors: asserted | Hydrating an ASD to the binodal gives a hydrophobic phase that is not in equilibrium with a dilute aqueous phase; the system lowers its free energy by PVPVA diffusing out of the ASD until the polymer/drug ratio reaches that of the dilute-solution binode (green tie line, Fig. 9) [rests on: argument only (Fig. 9)] | p.733 |

## 2024 Deac — Dissolution Mechanisms of Amorphous Solid Dispersions: Application of Ternary Phase Diagrams To Explain Release Behavior · Dissolution / A. Release mechanism and LoC

[2024-deac-asd-ternary-phase-diagrams-release](../../../cards/2024-deac-asd-ternary-phase-diagrams-release/paper.html) · Dissolution / A. Release mechanism and LoC · measured · as: tie line

| id | kind | content | locator |
|---|---|---|---|
| R15 | record, measured | total composition and equilibrium binode compositions (wt%, SD from n = 4 "except where noted"; no row is marked) — all equilibrated nondilute (P4) and dilute (P5) mixtures, 37 °C — sub-table below (rows are not labelled with the mixture in the source; see X12) | Table S1, SI p.6 |
| R22 | record, measured and simulated | MePHPH-PVPVA-water phase diagram — 37 °C; experimental binodes and tie lines from R15.a-e; film points from R2; PC-SAFT binodal, spinodal, tie lines, critical point (P19) — experimental and computed tie lines negatively sloped; the tie line of the lowest-water mixture (R15.d) does not pass through its total composition (text); inhomogeneous films at 10, 20 and 30% DL, 80% RH lie outside the computed binodal (text p.1911); computed critical point ≈29 wt% MePHPH, ≈59 wt% PVPVA, ≈12 wt% water (read from Fig. 9) | Fig. 9, p.1910; text p.1910-1911 |
| R23 | record, measured and simulated | PHPH-PVPVA-water phase diagram — 37 °C; experimental binodes and tie lines from R15.f-i; homogeneous mixtures R15.j-l; PC-SAFT (P19) — experimental and computed tie lines positively sloped and close in slope; the homogeneous mixtures R15.j-l lie inside the computed binodal; computed critical point ≈2.6 wt% PHPH, ≈59.5 wt% PVPVA, ≈38 wt% water (read from Fig. 10) | Fig. 10, p.1910; text p.1911 |
| R25 | record, simulated and measured | TIPP and MeTIPP computed diagrams with dilute experimental tie-line slope — P6, P19; 37 °C — plait point ≈10 wt% TIPP, ≈62 wt% PVPVA, ≈29 wt% water; plait point ≈23 wt% MeTIPP, ≈46 wt% PVPVA, ≈31 wt% water; dilute tie-line slope (PVPVA:drug of hydrophobic phase) ≈0.6 for TIPP and ≈0.2 for MeTIPP (all read from Fig. S17); numerical dilute compositions not printed | Fig. S17, SI p.23; SI p.8-9 |
| C31 | claim, caveat, authors: asserted | Tie lines must pass through the total composition; this held for most mixtures except the lowest-water one, where high viscosity hindered complete phase isolation, though its tie line follows the trend of the others [rests on: R15.d, R22] | p.1910 |