# Evidence: steric hindrance

Parent: — · class: molecular interaction · names merged here: steric effects; steric hindrance

3 papers measured or used it, 1 only mentioned it (of 207 kept papers). Papers in year order; each section heading ends with the paper's category / subcategory. Generated by tools/build_evidence.py from registry/concepts.csv and the cards; do not edit.

## 2011 Eerdenbrugh — An ab initio polymer selection methodology to prevent crystallization in amorphous solid dispersions by application of crystal engineering principles · Solid state stability / Miscibility and drug-polymer interactions

[2011-van-eerdenbrugh-ab-initio-polymer-selection-asd-crystallization](../../../cards/2011-van-eerdenbrugh-ab-initio-polymer-selection-asd-crystallization/paper.html) · Solid state stability / Miscibility and drug-polymer interactions · used · as: steric hindrance

| id | kind | content | locator |
|---|---|---|---|
| C40 | claim, mechanism, authors: "might still be able"; "might explain" | Polymers without donors are expected to perform worst for lidocaine, although strong acceptors might still bind the amide hydrogen; acceptor strength alone predicts PVP > PVPVA > E100, and steric factors (the N–H sits on a ring with two ortho methyl groups) might explain why the opposite order is observed [rests on: R3.m, R2.a–f] | p.6176 |
| C46 | claim, mechanism, authors: "seems"; "is apparent" | PVP, the strongest acceptor, still seems to suffer some steric hindrance relative to E100 for dibucaine, less marked than for lidocaine; the stronger acceptor effect of pyrrolidone over ester is apparent from PVP performing better than PVPVA [rests on: R3.o, R2.a–f] | p.6176 |

## 2018 Mosqueragiraldo — Crystallization Inhibition Properties of Cellulose Esters and Ethers for a Group of Chemically Diverse Drugs - Experimental and Computational Insight · Dissolution / D. Crystallization from solution

[2018-mosquera-giraldo-cellulose-esters-ethers-crystallization-inhibition-computational-insight](../../../cards/2018-mosquera-giraldo-cellulose-esters-ethers-crystallization-inhibition-computational-insight/paper.html) · Dissolution / D. Crystallization from solution · used · as: steric effects

| id | kind | content | locator |
|---|---|---|---|
| C44 | claim, mechanism, authors: "clearly"; "likely"; "may contribute" | Interaction with the emerging nucleus is a prerequisite for disrupting nucleation (ref 62), so polysaccharides with little interaction will be ineffective; for favourably interacting polymers the extent of disruption likely also depends on how far drug self-association is disrupted, where steric factors such as side-chain bulkiness may contribute [rests on: R12; cited: ref 62] | p.29 |

## 2020 Que — Evidence for Halogen Bonding in Amorphous Solid Dispersions · Solid state stability / Miscibility and drug-polymer interactions

[2020-que-halogen-bonding-amorphous-solid-dispersions](../../../cards/2020-que-halogen-bonding-amorphous-solid-dispersions/paper.html) · Solid state stability / Miscibility and drug-polymer interactions · used · as: steric hindrance

| id | kind | content | locator |
|---|---|---|---|
| C28 | claim, mechanism, authors: "potentially" | Br is potentially more structurally hindered than Cl as a halogen-bond donor [rests on: R5, R6] | SI p. 8 |
| C32 | claim, mechanism, authors: "may"; "further suggests possible" | The saturation may be at least partly due to steric constraints [rests on: R16] | p. 30 |

## Mentioned only

- 2013 Ilevbare — [2013-ilevbare-polymers-crystal-growth-structurally-diverse-compounds](../../../cards/2013-ilevbare-polymers-crystal-growth-structurally-diverse-compounds/paper.html) · Dissolution / D. Crystallization from solution (ref 23)