# Evidence: polymer-surfactant complexation

Parent: polymer-surfactant interaction · class: molecular interaction · names merged here: polymer-surfactant complex; polymer–surfactant complexation

2 papers measured or used it, 0 only mentioned it (of 207 kept papers). Papers in year order; each section heading ends with the paper's category / subcategory. Generated by tools/build_evidence.py from registry/concepts.csv and the cards; do not edit.

## 2015 Chen — Impact of Surfactants on the Crystallization of Aqueous Suspensions of Celecoxib Amorphous Solid Dispersion Spray Dried Particles · Dissolution / B. Supersaturation from ASD dissolution

[2015-chen-surfactants-crystallization-celecoxib-hpmcas-asd-suspensions](../../../cards/2015-chen-surfactants-crystallization-celecoxib-hpmcas-asd-suspensions/paper.html) · Dissolution / B. Supersaturation from ASD dissolution · used · as: polymer–surfactant complexation

| id | kind | content | locator |
|---|---|---|---|
| C32 | claim, mechanism, authors: "most likely" | SDS raises HPMCAS solubility most likely by forming polymer–surfactant complexes, as reported for HPMC–SDS. [rests on: R18.a; cited: ref 17, ref 18] | Discussion pp. 24–25 |

## 2016 Li — Leaching of Lopinavir Amorphous Solid Dispersions in Acidic Media · Dissolution / B. Supersaturation from ASD dissolution

[2016-li-lopinavir-asd-leaching-acidic-media](../../../cards/2016-li-lopinavir-asd-leaching-acidic-media/paper.html) · Dissolution / B. Supersaturation from ASD dissolution · used · as: polymer-surfactant complex

| id | kind | content | locator |
|---|---|---|---|
| C31 | claim, mechanism, authors: "These data suggest"; "may be able to" | PVPVA and SDS may form a complex with a higher solubilizing capacity for LPV than either alone [rests on: R17, R18, R5.d] | pdf p.7 |
| C41 | claim, prior hypothesis, authors: asserted; "can be" | Surfactants form complexes with polymers and start to aggregate at a CAC that is usually well below the CMC (for SDS by over two orders of magnitude), so solutes can be solubilized below the CMC; complexes form for several polymer–surfactant charge pairs, and their solubilizing power varies by solute and system [rests on: cited: refs 24–30] | pdf p.11 |
| C43 | claim, conclusion, authors: asserted ("clearly") | The SDS–PVPVA complex clearly has a higher solubilizing capacity for LPV than SDS alone; enhanced solubilization was also found for STC with HPMCAS HF and with HPMCP [rests on: R5] | pdf p.11 |
| C44 | claim, mechanism, authors: "can also enhance" | Surfactant–polymer complexation can also raise polymer solubility, which matches the higher HPMCAS leaching seen with SDS [rests on: R8, R13.g–h; cited: ref 24] | pdf p.11 |