# Evidence: phase separation kinetics

Parent: — · class: kinetics · names merged here: phase separation kinetics

2 papers measured or used it, 1 only mentioned it (of 207 kept papers). Papers in year order; each section heading ends with the paper's category / subcategory. Generated by tools/build_evidence.py from registry/concepts.csv and the cards; do not edit.

## 2020 Saboo — Patterns of drug release as a function of drug loading from amorphous solid dispersions: A comparison of five different polymers. · Dissolution / A. Release mechanism and LoC

[2020-saboo-asd-drug-loading-polymer-hydrophobicity-release](../../../cards/2020-saboo-asd-drug-loading-polymer-hydrophobicity-release/paper.html) · Dissolution / A. Release mechanism and LoC · used · as: phase separation kinetics

| id | kind | content | locator |
|---|---|---|---|
| C39 | claim, prior hypothesis, authors: "it has been suggested"; "is expected" | Water can impair ASD miscibility and cause water-induced AAPS on hydration, expected to harm dissolution; its thermodynamic favourability depends on DL, polymer type, the relative affinity of drug and polymer for water and the water absorbed (which depends on drug-polymer interactions); its kinetics compete with dissolution [rests on: cited: refs 30, 29, 34, 35, 22, 13, 36, 16, 6, 33] | p.12 |
| C41 | claim, mechanism, authors: "may be key"; "thought to be the case" | Competition between AAPS and dissolution may decide the regime: if dissolution is faster (thought to be so for the ≤10% DL ASDs here, whatever the polymer), drug and polymer release congruently and the surface keeps its composition; if AAPS is faster, drug- and polymer-rich domains dissolve at rates set by their composition, the polymer leaves first, the surface turns drug-rich and drug release slows [rests on: argument only; R14] | p.12 |
| C42 | claim, mechanism, authors: "may also be"; "likely" | At low DL too little drug for a contiguous drug-rich layer, and possibly a lower tendency or slower kinetics of AAPS, likely keep release congruent; at higher DL a greater tendency or rate of AAPS gives surface drug enrichment, which is a physical barrier to polymer release from subsurface layers and lowers drug release towards that of neat amorphous drug [rests on: R14, R22, R19] | p.12 |

## 2021 Saboo — Exploring the Role of Surfactants in Enhancing Drug Release from Amorphous Solid Dispersions at Higher Drug Loadings · Dissolution / A. Release mechanism and LoC

[2021-saboo-tpgs-felodipine-pvpva-asd-release-high-loading](../../../cards/2021-saboo-tpgs-felodipine-pvpva-asd-release-high-loading/paper.html) · Dissolution / A. Release mechanism and LoC · used · as: phase separation kinetics

| id | kind | content | locator |
|---|---|---|---|
| C38 | claim, assumption, authors: "assuming" | Phase separation in the hydrated matrix occurs faster than polymer dissolution [rests on: argument only] | p.17 |
| C41 | claim, mechanism, authors: "may"; "is anticipated" | Alternatively, the surfactant may slow phase separation; if phase separation in the gel layer is slower than polymer dissolution, congruent release is expected [rests on: argument only] | p.17 |
| C52 | claim, caveat, authors: "it is unclear"; "are likely to be useful" | It is unclear whether the surfactant slows phase separation so that molecular drug releases and then undergoes liquid-liquid phase separation, or whether nanoparticles form in the hydrated matrix and are kept from ripening; methods that capture the evolving ASD-water interface are needed [rests on: argument only] | p.19 |

## Mentioned only

- 2017 Saboo — [2017-saboo-water-induced-miconazole-pvpva-asd-phase-separation](../../../cards/2017-saboo-water-induced-miconazole-pvpva-asd-phase-separation/paper.html) · Solid state stability / Physical stability (ref 34)