# Evidence: Nernst-Brunner equation

Parent: — · class: transport and absorption · names merged here: Nernst-Brunner equation

2 papers measured or used it, 1 only mentioned it (of 207 kept papers). Papers in year order; each section heading ends with the paper's category / subcategory. Generated by tools/build_evidence.py from registry/concepts.csv and the cards; do not edit.

## 2019 Indulkar — Insights into the dissolution mechanism of ritonavir-copovidone amorphous solid dispersions: importance of congruent release for enhanced performance · Dissolution / A. Release mechanism and LoC

[2019-indulkar-ritonavir-copovidone-asd-congruent-release-loc](../../../cards/2019-indulkar-ritonavir-copovidone-asd-congruent-release-loc/paper.html) · Dissolution / A. Release mechanism and LoC · used · as: Nernst-Brunner equation

| id | kind | content | locator |
|---|---|---|---|
| E2 | equation | Nernst-Brunner equation: dC/dt = (DA/(Vh))(C_s − C) | p.12 |
| C22 | claim, assumption, authors: asserted ("must be employed"; equations "suggest") | Dissolution rate follows the Noyes-Whitney and Nernst-Brunner equations, with the solubility of the solid form at the dissolving surface (amorphous solubility for an amorphous surface); the rate approaches zero as the bulk concentration approaches that solubility [rests on: E1, E2; cited: refs 35-37] | p.11-12 |
| C42 | claim, conclusion, authors: "in agreement with"; "Further support" | No RTV release from the 50% DL ASD into RTV-saturated medium agrees with eq 2: the driving force from an RTV-rich surface is zero; this further supports a drug-rich interface and drug-controlled dissolution [rests on: R12.e-f, R13, E2] | p.17 |
| C48 | claim, generalisation, authors: asserted ("can only") | LLPS can occur during ASD dissolution only if release is controlled by components that dissolve faster than the drug; drug-controlled release slows toward zero as the drug approaches its amorphous solubility (eq 2) and never produces LLPS [rests on: E2, R12.e-f, R13] | p.18 |

## 2022 Indulkar — Role of Surfactants on Release Performance of Amorphous Solid Dispersions of Ritonavir and Copovidone · Dissolution / A. Release mechanism and LoC

[2022-indulkar-surfactants-ritonavir-copovidone-asd-release-performance](../../../cards/2022-indulkar-surfactants-ritonavir-copovidone-asd-release-performance/paper.html) · Dissolution / A. Release mechanism and LoC · used · as: Nernst-Brunner equation

| id | kind | content | locator |
|---|---|---|---|
| E2 | equation | Nernst-Brunner equation: (dC/dt)_drug = (D A / (V h)) (C_s − C) | p.391-392 |
| C21 | claim, prior hypothesis, authors: asserted ("clearly demonstrated") | At high DL dissolution is drug-controlled and can be approximated by the Nernst-Brunner equation (Eq. 2) from the amorphous solubility; release halts when the bulk concentration reaches the amorphous solubility [rests on: cited: ref 30; R3] | p.390, p.392 |

## Mentioned only

- 2022 Correasoto — [2022-correa-soto-surfactants-higher-drug-loading-atazanavir-pvpva-asds](../../../cards/2022-correa-soto-surfactants-higher-drug-loading-atazanavir-pvpva-asds/paper.html) · Dissolution / A. Release mechanism and LoC (ref E4)