# Evidence: kinetic stabilization

Parent: — · class: kinetics · names merged here: kinetic stabilization; polymer kinetic stabilization of amorphous drugs

2 papers measured or used it, 1 only mentioned it (of 207 kept papers). Papers in year order; each section heading ends with the paper's category / subcategory. Generated by tools/build_evidence.py from registry/concepts.csv and the cards; do not edit.

## 2006 Marsac — Theoretical and Practical Approaches for Prediction of Drug–Polymer Miscibility and Solubility · Solid state stability / Miscibility and drug-polymer interactions

[2006-marsac-drug-polymer-miscibility-solubility](../../../cards/2006-marsac-drug-polymer-miscibility-solubility/paper.html) · Solid state stability / Miscibility and drug-polymer interactions · used · as: kinetic stabilization

| id | kind | content | locator |
|---|---|---|---|
| C42 | claim, generalisation, authors: "seems unlikely"; "suggesting" | As pure nifedipine and felodipine nucleate much faster than dispersions with even small amounts of polymer, the reduced driving force seems unlikely to account for the reduced crystallization tendency, so kinetic and/or interfacial energy factors are of great importance ("as demonstrated here quantitatively for the first time") [rests on: R12, R16] | p.2423 |
| C56 | claim, generalisation, authors: abstract: "suggesting"; p.2424: "also suggests"; p.2425: "can therefore be attributed predominantly" | Physical stabilization of APIs in amorphous molecular-level solid dispersions is largely due to altered kinetics; abstract: kinetic rather than thermodynamic stabilization plays a significant role; conclusions: crystallization inhibition can be attributed predominantly to kinetic stabilization [rests on: R17, R12, R16] | p.2417, p.2424, p.2425 |
| X12 | extractor note | claim-data gap — C56 attributes stabilization "predominantly to a kinetic stabilization" and C42 points to kinetic and/or interfacial energy factors, but the paper measures no crystallization, nucleation or mobility; the kinetic reading rests on the small predicted ΔGv change (R12), the low predicted solubility (R17) and cited nucleation rates (R16) — C56, C42, R12, R16, R17 — treat kinetic stabilization as inferred by elimination, not measured here |  |

## 2009 Marsac — Estimation of Drug–Polymer Miscibility and Solubility in Amorphous Solid Dispersions Using Experimentally Determined Interaction Parameters · Solid state stability / Miscibility and drug-polymer interactions

[2009-marsac-drug-polymer-miscibility-solubility-asd-interaction-parameters](../../../cards/2009-marsac-drug-polymer-miscibility-solubility-asd-interaction-parameters/paper.html) · Solid state stability / Miscibility and drug-polymer interactions · used · as: kinetic stabilization

| id | kind | content | locator |
|---|---|---|---|
| C34 | claim, generalisation, authors: "It is clear that these predictions suggest"; "most likely" | The predictions suggest a thermodynamic driving force for crystallization at most practical polymer concentrations; thermodynamically stable solid dispersions are difficult to achieve and any apparent stability is most likely achieved through modification of the kinetics [rests on: R11, R9] | p.148 |

## Mentioned only

- 2015 Trasi — [2015-trasi-taylor-binary-amorphous-drug-combinations-supersaturation](../../../cards/2015-trasi-taylor-binary-amorphous-drug-combinations-supersaturation/paper.html) · Dissolution / B. Supersaturation from ASD dissolution (ref 13)