# Evidence: dynamic adsorption-desorption equilibrium

Parent: — · class: thermodynamics · names merged here: dynamic adsorption equilibrium; dynamic adsorption-desorption equilibrium

2 papers measured or used it, 0 only mentioned it (of 207 kept papers). Papers in year order; each section heading ends with the paper's category / subcategory. Generated by tools/build_evidence.py from registry/concepts.csv and the cards; do not edit.

## 2018 Dening — Supersaturation Potential of Ordered Mesoporous Silica Delivery Systems. Part 1: Dissolution Performance and Drug Membrane Transport Rates · Mesoporous silica / Mesoporous silica

[2018-dening-ordered-mesoporous-silica-supersaturation-dissolution-flux](../../../cards/2018-dening-ordered-mesoporous-silica-supersaturation-dissolution-flux/paper.html) · Mesoporous silica / Mesoporous silica · used · as: dynamic adsorption equilibrium

| id | kind | content | locator |
|---|---|---|---|
| C4 | claim, mechanism, authors: abstract: "suggest"; results: "appears to exist", "provides evidence that an equilibrium indeed exists"; discussion: "support the hypothesis"; conclusions: "suggesting" | An equilibrium exists between drug adsorbed to the SBA-15 surface and free drug in solution [rests on: R13, R14, R16, R17, R23] | p.3489, p.3494, p.3497, p.3499 |
| C53 | claim, mechanism, authors: "can be considered"; "can be explained" | Release from SBA-15 is a dynamic equilibrium in which water displaces adsorbed drug (E4); a higher dose and theoretical supersaturation shift it toward adsorbed drug, which explains the falling percent release [rests on: R23, E4; cited: ref 57] | p.3498 |
| E4 | equation | adsorption–displacement equilibrium: adsorbed drug + solvent in solution ⇌ adsorbed solvent + drug in solution | p.3498 |
| C47 | claim, mechanism, authors: "may therefore depend only in part" | Forward release (≈50% retained) and reverse adsorption (20% adsorbed) disagree, so drug retention in OMS may depend only in part on the adsorption equilibrium; further exploration is warranted [rests on: R6, R13, R30] | p.3498 |

## 2020 Mccarthy — A Comparison of Drug Release and Adsorption Under Supersaturating Conditions for Ordered Mesoporous Silica with Indomethacin or Indomethacin Methyl Ester · Mesoporous silica / Mesoporous silica

[2020-mccarthy-indomethacin-indme-sba15-adsorption-release](../../../cards/2020-mccarthy-indomethacin-indme-sba15-adsorption-release/paper.html) · Mesoporous silica / Mesoporous silica · measured · as: dynamic adsorption-desorption equilibrium

| id | kind | content | locator |
|---|---|---|---|
| R24 | record, measured | dissolution of the recovered solid (µg/mL, n = 1) — P15 — sub-table below (≈, read from Fig. 13); text: Cmax 16.2 µg/mL (IND) and 3.5 µg/mL (INDME), "43 % and 35 % release"; profiles not statistically significantly different from the original dissolution (p > 0.05); right-hand % axes give ≈40% and ≈37% at Cmax | p.31; Fig. 13, p.32 |
| R26 | record, derived (relation named, not printed) | drug remaining adsorbed after release versus amount adsorbed in the isotherm at Ci equal to the amorphous solubility (mmol/g) — release P14 (dose 35 and 9 µg/mL); isotherm P7 — after release 0.2 (IND) and 0.3 (INDME); isotherm 0.38 (IND) and 0.41 (INDME) | p.32 |
| E5 | equation | adsorbed drug-solvent exchange equilibrium: Adsorbed drug + solvent in solution ⇌ Adsorbed solvent + drug in solution | p.38 |
| C38 | claim, mechanism, authors: "provides further evidence"; "Interestingly" | Re-dissolution of the harvested solid gave profiles not significantly different from the original (p > 0.05), further evidence of a dynamic equilibrium between adsorbed and free drug; the extent of release was unchanged although the silica was approximately doubled [rests on: R24, R25, R20] | p.31 |
| C47 | claim, mechanism, authors: asserted; "consistent with" | The steep rise in adsorption as supersaturation approaches the amorphous solubility has implications for release; the further release from the isolated solid in fresh medium is consistent with a dynamic equilibrium between dissolved and adsorbed drug (Eq. 5) [rests on: R7, R8, R20, R24; cited: ref 24] | p.37-38 |