# Evidence: drug-polymer-water miscibility

Parent: drug-polymer miscibility · class: phase behaviour · names merged here: drug-polymer miscibility in the presence of water; drug–polymer–water miscibility

2 papers measured or used it, 0 only mentioned it (of 207 kept papers). Papers in year order; each section heading ends with the paper's category / subcategory. Generated by tools/build_evidence.py from registry/concepts.csv and the cards; do not edit.

## 2017 Indulkar — Origin of Nanodroplet Formation upon Dissolution of an Amorphous Solid Dispersion: A Mechanistic Isotope Scrambling Study · Dissolution / A. Release mechanism and LoC

[2017-indulkar-origin-nanodroplet-formation-asd-isotope-scrambling](../../../cards/2017-indulkar-origin-nanodroplet-formation-asd-isotope-scrambling/paper.html) · Dissolution / A. Release mechanism and LoC · used · as: drug-polymer miscibility in the presence of water

| id | kind | content | locator |
|---|---|---|---|
| C38 | claim, generalisation, authors: "are expected" | AAPS depends on drug–polymer miscibility in the presence of water, set by the balance of drug, polymer and water interactions, and varies with drug, polymer type and composition; drug–PVPVA ASDs that dissolve rapidly while staying miscible in water are expected to form nanospecies via mechanism I [rests on: cited: refs 46-48; argument only] | pdf p.20 |

## 2023 Yang — Drug Release from Surfactant-Containing Amorphous Solid Dispersions: Mechanism and Role of Surfactant in Release Enhancement · Dissolution / A. Release mechanism and LoC

[2023-yang-surfactant-containing-asd-release-enhancement](../../../cards/2023-yang-surfactant-containing-asd-release-enhancement/paper.html) · Dissolution / A. Release mechanism and LoC · measured · as: drug–polymer–water miscibility

| id | kind | content | locator |
|---|---|---|---|
| R21 | record, measured (RH); derived (P11, water content) | minimum RH and water content (% of dry solid mass) at which phase separation was observed — 30% DL films, 12 h storage (P12) — see R21 sub-table | Table II, p.2840; text p.2834 |
| C9 | claim, conclusion, authors: abstract: asserted ("Importantly"); results: suggesting; conclusion: asserted | SDS increased the miscibility of the RTV–PVPVA–water system (more water needed for AAPS, reduced miscibility gap); water contents needed were similar for the other formulations, so surfactants altered the thermodynamics of phase separation. [rests on: R21, R13] | Abstract, p.2817; Results, p.2834; Conclusion, p.2843 |
| C10 | claim, mechanism, authors: results: suggested; discussion: likely, suggests | For SDS ASDs, AAPS was limited to the very surface of the gel where water content is highest, the ASD could dissolve without phase separating, and this change in miscibility gap is likely responsible for the improved release. [rests on: R13, R19, R21; cited: R25] | Results, p.2829; Discussion, p.2837 |