# Evidence: drug adsorption onto silica

Parent: — · class: molecular interaction · names merged here: drug adsorption onto silica; drug adsorption to silica

2 papers measured or used it, 0 only mentioned it (of 207 kept papers). Papers in year order; each section heading ends with the paper's category / subcategory. Generated by tools/build_evidence.py from registry/concepts.csv and the cards; do not edit.

## 2018 Dening — Supersaturation Potential of Ordered Mesoporous Silica Delivery Systems. Part 1: Dissolution Performance and Drug Membrane Transport Rates · Mesoporous silica / Mesoporous silica

[2018-dening-ordered-mesoporous-silica-supersaturation-dissolution-flux](../../../cards/2018-dening-ordered-mesoporous-silica-supersaturation-dissolution-flux/paper.html) · Mesoporous silica / Mesoporous silica · measured · as: drug adsorption to silica

| id | kind | content | locator |
|---|---|---|---|
| R13 | record, measured | ritonavir concentration after blank SBA-15 was added to a 28 µg/mL ritonavir solution — P8 (a); blank SBA-15 ≈100 µg/mL; buffer; 2 h; n = 2, mean ± range — ≈22.7 (5 min), ≈22.6 (15), ≈22.6 (30), ≈22.3 (60), ≈22.3 (90), ≈22.0 µg/mL (120) (read from Fig. 3); text: decreased from 28 to ≈22 µg/mL, stable over 2 h; discussion: 22.7 ± 0.5 µg/mL after 15 min equilibration, 20% adsorbed, ≈80% left in solution | Fig. 3, p.3493; text p.3493, p.3497-3498 |
| R14 | record, measured | ritonavir concentration after loaded SBA-15 was added to a medium presaturated at 28 µg/mL — P8 (b); total theoretical 56 µg/mL; n = 2, mean ± range — ≈17.4 (5 min), ≈17.9 (15), ≈18.7 (30), ≈19.6 (60), ≈20.4 (90), ≈20.3 µg/mL (120) (read from Fig. 4); text: 17 to 20 µg/mL over 2 h, below the starting 28 µg/mL | Fig. 4, p.3493 |
| R15 | record, derived (relation not printed) | ritonavir taken up by the formulation in the R14 test — P8 (b) — solution 28 → ≈20 µg/mL; additional 600 µg ritonavir adsorbed; 27% w/w ritonavir on the formulation | p.3499 |
| C23 | claim, mechanism, authors: "suggesting" | The drop from 28 to 22 µg/mL on adding blank SBA-15 points to strong adsorptive interactions between ritonavir and SBA-15 in solution [rests on: R13] | p.3493 |
| C24 | claim, conclusion, authors: asserted ("it is clear") | SBA-15 adsorbed additional ritonavir from solution even when loaded at theoretical monolayer coverage [rests on: R14] | p.3493 |

## 2020 Hate — Influence of Drug-Silica Electrostatic Interactions on Drug Release from Mesoporous Silica-Based Oral Delivery Systems · Mesoporous silica / Mesoporous silica

[2020-hate-drug-silica-electrostatic-interactions-mesoporous-release](../../../cards/2020-hate-drug-silica-electrostatic-interactions-mesoporous-release/paper.html) · Mesoporous silica / Mesoporous silica · measured · as: drug adsorption onto silica

| id | kind | content | locator |
|---|---|---|---|
| R3 | record, measured | KET adsorption isotherms on SBA-15 (amount adsorbed in mg/g versus equilibrium concentration in µg/mL; mean ± SD, n = 3) — P2; pH 1, 4.5, 5.5, 6.8; 37 °C; 9-11 points per pH — sub-table below; text: low adsorption at pH 1; notable increase at pH 4.5 with further slight increases at pH 5.5 and 6.8 | Fig. 3a, p.13; text p.12 |
| R4 | record, measured | CLZ adsorption isotherms on SBA-15 (as R3) — P2; pH 4.5, 5.5, 6.8; 37 °C; 8-9 points per pH — sub-table below; text: no adsorption in more acidic media, so pH 1 data are not plotted; adsorption increased substantially from pH 4.5 to pH 6.8 | Fig. 3b, p.13; text p.12 |
| R5 | record, measured | ATZ adsorption isotherms on SBA-15 (as R3) — P2; pH 1, 4.5, 5.5, 6.8; 37 °C; 10-12 points per pH — sub-table below; text: higher adsorption at pH 1 and 4.5 than at pH 5.5; at pH 6.8 the amount adsorbed decreased by half | Fig. 3c, p.13; text p.12 |
| R14 | record, measured | amount of drug adsorbed on SBA-15 at pH 6.8 with competing adsorbates (mg/g, bars with error bars) — P3; KET and CLZ; 0.5 M urea or 50 mM TEA — sub-table below; text: KET and CLZ adsorption reduced drastically with TEA; with urea a small reduction for KET and no difference for CLZ | Fig. 6, p.17; text p.17 |
| R20 | record, derived (E3) | amount adsorbed (mg/g) versus solute activity at pH 6.8 — replot of the pH 6.8 isotherms of R3-R5 (P15) — highest activity and amount: KET ≈0.445 and ≈66; CLZ ≈0.19 and ≈53; ATZ ≈0.86 and ≈21; near activity 0.2: CLZ ≈53, KET ≈18.5, ATZ ≈5 at ≈0.25 (all read from Fig. S5) | Fig. S5, SI p.4 |
| R21 | record, derived (E2) | BET monolayer coverage Qm (unit printed "mg/mol") — fits of the Fig. 3 isotherms (P14) — sub-table below (transcribed in full) | Table S1, SI p.4; text p.22 |
| E4 | equation | solution-depletion mass balance: amount adsorbed = amount of drug at the initial concentration minus amount at the equilibrium concentration (printed in words) | p.8 |