# Evidence: dipole-dipole interactions

Parent: — · class: molecular interaction · names merged here: dipole-dipole interaction; dipole-dipole interactions

2 papers measured or used it, 0 only mentioned it (of 207 kept papers). Papers in year order; each section heading ends with the paper's category / subcategory. Generated by tools/build_evidence.py from registry/concepts.csv and the cards; do not edit.

## 2009 Marsac — Estimation of Drug–Polymer Miscibility and Solubility in Amorphous Solid Dispersions Using Experimentally Determined Interaction Parameters · Solid state stability / Miscibility and drug-polymer interactions

[2009-marsac-drug-polymer-miscibility-solubility-asd-interaction-parameters](../../../cards/2009-marsac-drug-polymer-miscibility-solubility-asd-interaction-parameters/paper.html) · Solid state stability / Miscibility and drug-polymer interactions · used · as: dipole-dipole interaction

| id | kind | content | locator |
|---|---|---|---|
| R12 | record, simulated and measured per column | dipole moment (P5) and shift of the PVP C=O band in a dispersion with one donor group per carbonyl acceptor (P4) — single molecules (dipole); amorphous dispersions with PVP (shift) — sub-table below; text: shifts are to lower wavenumber | Table IV, p.148 |
| C41 | claim, mechanism, authors: "it seems reasonable to speculate"; "may therefore"; "is also believed"; "highlight" | It seems reasonable to speculate that ketoconazole and PVP interact by dipole–dipole interactions; ketoconazole's large calculated dipole moment means it may interact strongly with polar molecules such as PVP, and its large size is believed to add considerable van der Waals interaction; interactions other than hydrogen bonds therefore need consideration [rests on: R12.h; argument only] | p.149 |

## 2009 Rumondor — Evaluation of Drug-Polymer Miscibility in Amorphous Solid Dispersion Systems · Solid state stability / Miscibility and drug-polymer interactions

[2009-rumondor-drug-polymer-miscibility-asd-dsc-ir-pxrd](../../../cards/2009-rumondor-drug-polymer-miscibility-asd-dsc-ir-pxrd/paper.html) · Solid state stability / Miscibility and drug-polymer interactions · used · as: dipole-dipole interactions

| id | kind | content | locator |
|---|---|---|---|
| C23 | claim, mechanism, authors: "It is speculated" | The relative-intensity differences in ketoconazole-PVP are speculated to come from dipole-dipole interactions between ketoconazole and PVP (compare ion-dipole interactions reported for PVP with MK-0591) [rests on: R10; cited: ref 29] | p.2528 |