# Evidence: crystal-melt interfacial free energy

Parent: interfacial free energy · class: thermodynamics · names merged here: crystal-melt interfacial energy; crystal-melt interfacial free energy

3 papers measured or used it, 0 only mentioned it (of 207 kept papers). Papers in year order; each section heading ends with the paper's category / subcategory. Generated by tools/build_evidence.py from registry/concepts.csv and the cards; do not edit.

## 2006 Marsac — A Comparison of the Physical Stability of Amorphous Felodipine and Nifedipine Systems · Solid state stability / Physical stability

[2006-marsac-physical-stability-amorphous-felodipine-nifedipine](../../../cards/2006-marsac-physical-stability-amorphous-felodipine-nifedipine/paper.html) · Solid state stability / Physical stability · used · as: crystal-melt interfacial energy

| id | kind | content | locator |
|---|---|---|---|
| C36 | claim, conclusion, authors: "Even if"; "would not account" | The interfacial term ΔGs is hard to measure for glasses; even if Turnbull's proportionality of interfacial energy to enthalpy of fusion held for organic glasses, it would not explain the faster nucleation of nifedipine, whose higher enthalpy of fusion would give the larger interfacial energy [rests on: R4.g, R22] | p.2313 |
| R22 | record, cited | crystal-melt interfacial energy — ref 43 (Turnbull 1950), metals — empirical proportionality between crystal-melt interfacial energy and enthalpy of fusion | p.2313 |

## 2010 Kestur — Effects of the Molecular Weight and Concentration of Polymer Additives, and Temperature on the Melt Crystallization Kinetics of a Small Drug Molecule · Solid state stability / Physical stability

[2010-kestur-pvp-mw-concentration-temperature-felodipine-melt-crystallization](../../../cards/2010-kestur-pvp-mw-concentration-temperature-felodipine-melt-crystallization/paper.html) · Solid state stability / Physical stability · used · as: crystal-melt interfacial free energy

| id | kind | content | locator |
|---|---|---|---|
| E3 | equation | two-dimensional nucleation barrier: ΔG* = −πbγ²/ΔGv | p.3592 |
| C27 | claim, mechanism, authors: asserted; "would lead to the opposite effect" | The remaining thermodynamic cause would be the crystal-melt interfacial free energy γ, but adsorption of the polymer to the crystal surface would decrease γ rather than increase it, so it does not fit [rests on: cited: ref 31] | p.3592 |

## 2017 Tian — Impact of Polymers on the Melt Crystal Growth Rate of Indomethacin Polymorphs · Solid state stability / Physical stability

[2017-tian-polymers-melt-crystal-growth-indomethacin-polymorphs](../../../cards/2017-tian-polymers-melt-crystal-growth-indomethacin-polymorphs/paper.html) · Solid state stability / Physical stability · used · as: crystal-melt interfacial free energy

| id | kind | content | locator |
|---|---|---|---|
| C26 | claim, mechanism, authors: discussion: "may arise"; conclusion: "suggesting" | The growth-rate differences between the polymorphs may arise from the kinetics of integration at the crystal-liquid interface, which depends on the interface structure (conclusion: the varied rates suggest differences in the crystal-melt interface between polymorphs) [rests on: R7, R11] | p.17; p.19 |
| C38 | claim, prior hypothesis, authors: "suggested"; "attributed" | The impact of polymers on growth of different polymorphs has not been studied extensively; Kestur et al. suggested that PVP inhibited felodipine polymorph growth through its effect on the liquid phase, and Shuai et al. attributed the polymorph-dependent inhibition of itraconazole to polymer-induced changes in the crystal-melt interfacial free energy [rests on: cited: refs 26, 27; R17, R18] | p.18-19 |
| C39 | claim, mechanism, authors: "it appears" | Because the three polymers inhibit IDM polymorphs growing from the same liquid to different extents, the effect cannot be rationalized by the polymer's action on the liquid phase per se (for example on mobility); it appears that the polymers act on the crystal-melt interface of each polymorph differently [rests on: R12, R15] | p.19 |
| X14 | extractor note | claim-data gap — C39 (polymers act differently on the crystal-melt interface of each polymorph) and C26 are reached by excluding a liquid-phase explanation; no interfacial property was measured, although "interface free energy" is an author keyword — C39, C26, R12 — treat the interface explanation as a hypothesis |  |