# Evidence: binding constant

Parent: — · class: molecular interaction · names merged here: association equilibrium constant; binding constant

2 papers measured or used it, 0 only mentioned it (of 207 kept papers). Papers in year order; each section heading ends with the paper's category / subcategory. Generated by tools/build_evidence.py from registry/concepts.csv and the cards; do not edit.

## 1997 Taylor — Spectroscopic Characterization of Interactions Between PVP and Indomethacin in Amorphous Molecular Dispersions · Solid state stability / Miscibility and drug-polymer interactions

[1997-taylor-pvp-indomethacin-amorphous-molecular-dispersions](../../../cards/1997-taylor-pvp-indomethacin-amorphous-molecular-dispersions/paper.html) · Solid state stability / Miscibility and drug-polymer interactions · used · as: association equilibrium constant

| id | kind | content | locator |
|---|---|---|---|
| C37 | claim, conclusion, authors: "This is clearly not the case"; "This suggests" | Since spectral changes continue at PVP contents above both the 12% and the 24% values (R18), not all indomethacin is hydrogen-bonded at those contents, which suggests a low equilibrium constant for PVP-indomethacin species and/or a stoichiometry below 1:1 [rests on: R18, R11, R12] | p.1696 |
| C38 | claim, mechanism, authors: asserted; dimers: "may still be present" | At low PVP, indomethacin is present as dimers and PVP-indomethacin species with some free PVP; as PVP increases free PVP increases, and dimers may still be present depending on the equilibrium constant; the ratios of the species (Fig. 7) vary with PVP content [rests on: R11, R12, R18] | p.1696 |

## 2020 Que — Evidence for Halogen Bonding in Amorphous Solid Dispersions · Solid state stability / Miscibility and drug-polymer interactions

[2020-que-halogen-bonding-amorphous-solid-dispersions](../../../cards/2020-que-halogen-bonding-amorphous-solid-dispersions/paper.html) · Solid state stability / Miscibility and drug-polymer interactions · measured · as: binding constant

| id | kind | content | locator |
|---|---|---|---|
| E1 | equation | 1:1 association (binding) constant: K_F = [AD] / ([A][D]) | Eq. 1, p. 13 |
| R12 | record, measured | KF with EP in cyclohexane — P6; 25 °C; n = 3 titrations — sub-table R12 | Table 2, p. 24 |
| R13 | record, measured | KF with EP in toluene — P6; 25 °C — sub-table R13 | Table S3, SI p. 21 |