# Evidence: adsorption isotherm

Parent: — · class: thermodynamics · names merged here: adsorption isotherm

4 papers measured or used it, 0 only mentioned it (of 207 kept papers). Papers in year order; each section heading ends with the paper's category / subcategory. Generated by tools/build_evidence.py from registry/concepts.csv and the cards; do not edit.

## 2019 Dening — Application of an adsorption isotherm to explain incomplete drug release from ordered mesoporous silica materials under supersaturating conditions · Mesoporous silica / Mesoporous silica

[2019-dening-adsorption-isotherm-incomplete-release-sba15](../../../cards/2019-dening-adsorption-isotherm-incomplete-release-sba15/paper.html) · Mesoporous silica / Mesoporous silica · measured · as: adsorption isotherm

| id | kind | content | locator |
|---|---|---|---|
| R2 | record, measured; Qa derived (E1) | adsorption isotherm of ritonavir on SBA-15, Qa vs Ce — P3; Ci 0.625–30 μg/mL; mean ± SD, n = 3 — text: 39 ± 5 mg/g at Ci 0.625 μg/mL; 424 ± 29 mg/g at Ci 30 μg/mL; Ce at Ci 30 μg/mL approximately 25 μg/mL (p. 190); most Ci and Ce supersaturated; no crystallization observed over the experimental period; 14 points in sub-table R2 a–n (read from Fig. 1) | Fig. 1 and Section 4.2, p. 189; Section 4.3, p. 190 |
| E1 | equation | adsorption mass balance (batch depletion): Qa = (Ci − Ce)V/m | Eq. (1), p. 187 |
| C10 | claim, conclusion, authors: abstract: asserted; discussion: asserted ("clearly demonstrated") | SBA-15 adsorbed large amounts of ritonavir from solutions spanning below the crystalline solubility to slightly above the amorphous solubility, and adsorption increased with the extent of supersaturation. [rests on: R2] | Abstract, p. 186; Section 4.2, p. 189; Section 5.1, p. 194; Section 6, p. 198 |

## 2020 Hate — Interplay of Adsorption, Supersaturation and the Presence of an Absorptive Sink on Drug Release from Mesoporous Silica-Based Formulations · Mesoporous silica / Mesoporous silica

[2020-hate-atazanavir-mesoporous-silica-adsorption-absorptive-sink-release](../../../cards/2020-hate-atazanavir-mesoporous-silica-adsorption-absorptive-sink-release/paper.html) · Mesoporous silica / Mesoporous silica · measured · as: adsorption isotherm

| id | kind | content | locator |
|---|---|---|---|
| R2 | record, measured; BET column derived (E1) | ATZ adsorbed versus equilibrium concentration (mg/g; values read from Fig. 3a; error bars shown, meaning and n not stated) — SBA-15 300 µg/mL, 2 h, 37 °C, HPMC 0.1 mg/mL (P13) — sub-table below; type II shape (rise, plateau, further non-linear rise); text: maximum adsorbed "equivalent to 25 mg/g" at the amorphous solubility | Fig. 3a, p.6; text p.5-6 |
| R4 | record, measured; BET column derived (E1) | ATZ adsorbed versus equilibrium concentration (mg/g; values read from Fig. 3b) — SBA-15 25 µg/mL, otherwise as R2 (P13) — sub-table below; type II shape; text: mg/g significantly higher than with 300 µg/mL SBA-15 | Fig. 3b, p.6; text p.7 |
| C21 | claim, conclusion, authors: asserted | ATZ adsorption onto SBA-15 follows a type II isotherm, similar to that of the structural analogue ritonavir [rests on: R2, R4, R29] | p.5-6 |

## 2020 Hate — Influence of Drug-Silica Electrostatic Interactions on Drug Release from Mesoporous Silica-Based Oral Delivery Systems · Mesoporous silica / Mesoporous silica

[2020-hate-drug-silica-electrostatic-interactions-mesoporous-release](../../../cards/2020-hate-drug-silica-electrostatic-interactions-mesoporous-release/paper.html) · Mesoporous silica / Mesoporous silica · measured · as: adsorption isotherm

| id | kind | content | locator |
|---|---|---|---|
| R3 | record, measured | KET adsorption isotherms on SBA-15 (amount adsorbed in mg/g versus equilibrium concentration in µg/mL; mean ± SD, n = 3) — P2; pH 1, 4.5, 5.5, 6.8; 37 °C; 9-11 points per pH — sub-table below; text: low adsorption at pH 1; notable increase at pH 4.5 with further slight increases at pH 5.5 and 6.8 | Fig. 3a, p.13; text p.12 |
| R4 | record, measured | CLZ adsorption isotherms on SBA-15 (as R3) — P2; pH 4.5, 5.5, 6.8; 37 °C; 8-9 points per pH — sub-table below; text: no adsorption in more acidic media, so pH 1 data are not plotted; adsorption increased substantially from pH 4.5 to pH 6.8 | Fig. 3b, p.13; text p.12 |
| R5 | record, measured | ATZ adsorption isotherms on SBA-15 (as R3) — P2; pH 1, 4.5, 5.5, 6.8; 37 °C; 10-12 points per pH — sub-table below; text: higher adsorption at pH 1 and 4.5 than at pH 5.5; at pH 6.8 the amount adsorbed decreased by half | Fig. 3c, p.13; text p.12 |
| R20 | record, derived (E3) | amount adsorbed (mg/g) versus solute activity at pH 6.8 — replot of the pH 6.8 isotherms of R3-R5 (P15) — highest activity and amount: KET ≈0.445 and ≈66; CLZ ≈0.19 and ≈53; ATZ ≈0.86 and ≈21; near activity 0.2: CLZ ≈53, KET ≈18.5, ATZ ≈5 at ≈0.25 (all read from Fig. S5) | Fig. S5, SI p.4 |
| P2 | method | adsorption isotherm by solution depletion | p.8 |

## 2020 Mccarthy — A Comparison of Drug Release and Adsorption Under Supersaturating Conditions for Ordered Mesoporous Silica with Indomethacin or Indomethacin Methyl Ester · Mesoporous silica / Mesoporous silica

[2020-mccarthy-indomethacin-indme-sba15-adsorption-release](../../../cards/2020-mccarthy-indomethacin-indme-sba15-adsorption-release/paper.html) · Mesoporous silica / Mesoporous silica · measured · as: adsorption isotherm

| id | kind | content | locator |
|---|---|---|---|
| R7 | record, measured | IND adsorption isotherm, Qa (mg/g) versus Ce (µg/mL), mean (n = 3) — P7, IND Ci 1-60 µg/mL — sub-table below (all values ≈, read from Fig. 4a; individual Ci not given) | Fig. 4a, p.21 |
| R8 | record, measured | INDME adsorption isotherm, Qa (mg/g) versus Ce (µg/mL), mean (n = 3) — P7, INDME Ci 1-14 µg/mL — sub-table below (all values ≈, read from Fig. 4b; individual Ci not given) | Fig. 4b, p.21 |
| R12 | record, derived (E2) | adsorption isotherm on the activity scale, amount adsorbed (mmol/g) versus activity, mean (n = 3) — R7, R8 converted with P18 — sub-table below (all values ≈, read from Fig. 5) | Fig. 5, p.23 |
| R10 | record, derived (E6, E7, E8) | isotherm fit parameters — R7, R8 fitted with linear Langmuir and Freundlich and non-linear BET (P17) — sub-table below; BET KS, Freundlich n and Langmuir Qm not reported | Table 3, p.21-22 |