# Evidence: accelerated stability testing

Parent: — · class: measurement · names merged here: accelerated stability testing

3 papers measured or used it, 1 only mentioned it (of 207 kept papers). Papers in year order; each section heading ends with the paper's category / subcategory. Generated by tools/build_evidence.py from registry/concepts.csv and the cards; do not edit.

## 2009 Rumondor — Phase Behavior of Poly(vinylpyrrolidone) Containing Amorphous Solid Dispersions in the Presence of Moisture · Solid state stability / Physical stability

[2009-rumondor-pvp-asd-moisture-induced-immiscibility](../../../cards/2009-rumondor-pvp-asd-moisture-induced-immiscibility/paper.html) · Solid state stability / Physical stability · used · as: accelerated stability testing

| id | kind | content | locator |
|---|---|---|---|
| C52 | claim, generalisation, authors: "highlight"; "may" | Moisture-induced immiscibility at RH as low as 75 or 54% shows a problem with accelerated (high RH) stability conditions: in susceptible systems the crystallization route may change at high RH and not represent behaviour at lower RH [rests on: R10, R8, R13] | p.1505 |

## 2013 Kestur — Influence of particle size on the crystallization kinetics of amorphous felodipine powders · Solid state stability / Physical stability

[2013-kestur-particle-size-crystallization-amorphous-felodipine-pvp](../../../cards/2013-kestur-particle-size-crystallization-amorphous-felodipine-pvp/paper.html) · Solid state stability / Physical stability · measured · as: accelerated stability testing

| id | kind | content | locator |
|---|---|---|---|
| R9 | record, measured | % crystallinity versus time at 50 °C and 30 °C (Raman per text) — 3% PVP dispersion, size 1 — sub-table below; text at 50 °C: very slow crystallization for the first 5 days, rapid crystallization to 70% by 2 weeks, plateau at around 85% over the next 2 weeks | Fig. 7, p.201; text p.199 |
| R17 | record, derived (E2) | initial crystallization rate and plateau, 50 °C versus 30 °C — 3% PVP size 1 (Fig. 7) — initial crystallization ≈8 times faster at 50 °C (slope values not printed); plateau 85% versus 45% | p.202 |
| C38 | claim, conclusion, authors: asserted ("Interestingly") | At 50 °C the 3% PVP dispersion crystallizes about 8 times faster in the initial stage and to a much higher plateau (85% versus 45%) than at 30 °C [rests on: R9, R17] | p.202 |
| C40 | claim, recommendation, authors: asserted ("highlights") | The different rate and extent of crystallization at 50 °C highlight the difficulty of using accelerated storage conditions to predict crystallization at lower temperatures [rests on: R9, R17] | p.203 |

## 2013 Wegiel — Crystallization of Amorphous Solid Dispersions of Resveratrol during Preparation and Storage—Impact of Different Polymers · Solid state stability / Physical stability

[2013-wegiel-resveratrol-asd-polymer-crystallization-stability](../../../cards/2013-wegiel-resveratrol-asd-polymer-crystallization-stability/paper.html) · Solid state stability / Physical stability · used · as: accelerated stability testing

| id | kind | content | locator |
|---|---|---|---|
| P3 | method | isothermal storage stability | p.173, p.177, p.180 |
| C41 | claim, generalisation, authors: "highlight" | These observations highlight the difficulty of selecting appropriate conditions for accelerated stability testing [rests on: R12, R13, R14] | p.183 |

## Mentioned only

- 2011 Rumondor — [2011-rumondor-asd-moisture-aaps-pvp-opls](../../../cards/2011-rumondor-asd-moisture-aaps-pvp-opls/paper.html) · Solid state stability / Physical stability (ref C3)